BACKGROUND: Circadian ( approximately 24 hr) rhythms are generated by the central pacemaker localized to the suprachiasmatic nucleus (SCN) of the hypothalamus.Although the basis for intrinsic rhythmicity is generally understood to rely on transcription factors encoded by "clock genes", less is known about the daily regulation of SCN neuronal activi

BackgroundAtopic dermatitis (AD) is characterized by an altered skin microbiome dominantly colonized by S.aureus.Standard treatment includes emollients, anti-inflammatory medications and antiseptics.ObjectivesTo characterize changes in the skin microbiome during treatment for AD.MethodsThe skin microbiomes of children with moderate-to-severe AD and

Rapid adaptation to changes, while maintaining a certain level of behavioral inhibition is an important feature in every day functioning.How environmental context and challenges in life can impact on the development of this quality is still Classical Normal Tension unknown.In the present study, we examined the effect of a complex rearing environmen